@pbirke According to the Wikipedia page, the only system that would run on the Pi is the Nintendo DS, other consoles will not run on the Pi. There is a similar game (FoFix) that runs on the PI, but you'll need to install the desktop part to be able to run it.

I didn't map the X360 guitar controller before, because it was already working in EmulationStation and in Moonlight as well. I could navigate all the menus and select my games.

Now I did map my guitar controller and launched the game, but the problem persists. It seems, more and more, that this is a Phase Shift issue.